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KMID : 1123920090230051073
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 5 p.1073 ~ p.1079
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Effects of Yijin-tang-gamibang Extracts on Reflux Esophagitis
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Hwang Gee-Young
Kim Dae-Jun
Byun Joon-Seok
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Abstract
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The object of this study was to observe the protective effects of Yijin-tang-gamibang (YJGMB), Yijin-tang has been traditionally used as Korean medicine for treating various digestive diseases. The study showed that it is effective on reflux esophagitis induced by pylorus and forestomach ligation in rats. Three different dosages of Yijin-tang-gamibang extracts, 300, 150 and 75 ㎎/㎏, were once orally administered 1 hour before pylorus ligation. 6 groups, each of 8 rats per group were used in the present study. The results were compared with Omeprazole, antioxidant and proton pump inhibitor, 30 ㎎/㎏ treated group. Yijin-tang-gamibang extracts 300 ㎎/㎏ were showed similar or slightly lower effects as compared with 30 ㎎/㎏ of omeprazole in the present study. Detail mechanism studies should be conduced in future with the efficacy tests of individual herbal composition of Yijin-tang-gamibang and the screening of the biological active compounds in herbs.
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KEYWORD
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gastroesophageal reflux disease, Yijin-tang, omeprazole
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